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KMID : 0361120110250010015
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Korean Journal of Transplantation
2011 Volume.25 No. 1 p.15 ~ p.21
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Artificial Liver Devices and Bioartificial Liver Systems: Current Status
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Kwon Choon-Hyuck
Lee Suk-Koo
Park Jung-Keug
Lee Doo-Hoon
Lee Ji-Hyun
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Abstract
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Acute liver failure is a rapidly progressive disease of the liver associated with high morbidity and mortality without liver
transplantation. Although good survival after transplantation can be achieved, due to the disparity between patients awaiting
transplantation and available organs, many patients die due to progression of the disease while waiting for a liver graft.
To reduce the high morbidity and mortality associated with acute liver failure, attempts have been made during the last
several decades to develop a temporary liver support system, such as artificial and bioartificial livers. The artificial liver is
a non-biological device mainly aimed at the removal of accumulated toxins during liver failure, and the bioartificial liver
is a biological device that has bioreactors containing living hepatocytes which provide both biotransformation and synthetic
liver functions. There are currently 3 artificial livers available in the market that have been actively used in the clinical field,
and 11 bioartificial livers that have been developed and have undergone clinical trials. In this article, we will discuss about
the 3 artificial liver devices and 5 bioartificial liver systems that are the most advanced and have been widely evaluated
clinically. Also, the characteristics and the preclinical da
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KEYWORD
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Bioartificial liver, Artificial liver, Acute liver failure, Calcium alginate, Hepatic transplantation
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